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The majority of plasma fractionators use ethanol fractionation to manufacture proteins. The ethanol denatures some proteins and alpha-1 antitrypsin is one of them. Knowledge of the proteins present in fractions from the Kistler and Nitschmann process alongside chromatographic choices, has led us to design an efficient process for the manufacture of alpha-1 antitrypsin (AAT). AAT, a major inhibitor...
We report a novel method for the extraction of α-1 antitrypsin (AAT) from plasma. This method uses an anion-exchange column and two metal chelate columns. The AAT is recovered in a 60% yield and a purity of over 90%. The AAT manufactured by this method was stable at 4°C for 12 months without any stabilisers. Other proteins of therapeutic value and commercial interest are recoverable in good yields...
The analytical performance of an on-line sequential injection lab-on-valve (SI-LOV) system using chelating Sepharose beads as sorbent material for the determination of ultra-trace levels of Cd(II), Pb(II) and Ni(II) by electrothermal atomic absorption spectrometry (ETAAS) is described and discussed. The samples are adjusted to pH 5.0 on-line in the system for optimum operation. The target ions are...
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